Resources | Samson T. Jacob

Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma.

Ibrutinib Potentiates Antihepatocarcinogenic Efficacy of Sorafenib by Targeting EGFR in Tumor Cells and BTK in Immune Cells in the Stroma

The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128

Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis

Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis

Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog

Regulation of glucose metabolism in hepatocarcinogenesis by microRNAs

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor

Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate

Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes

Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

Lipid nanoparticles for hepatic delivery of small interfering RNA

Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Emerging role of microRNAs in drug-resistant breast cancer

Breast cancer. Introduction

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Role of cancer stem cells in hepatocarcinogenesis

Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes

Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib

HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia

Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade

Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation

Downregulation of miR-122 in the rodent and human hepatocellular carcinomas

Role of protein tyrosine phosphatases in cancer

A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats

Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1

Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1

Suppression of metallothionein-I/II expression and its probable molecular mechanisms

Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure

Analysis of promoter methylation and its role in silencing metallothionein I gene expression in tumor cells

Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms

Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I

Regulation of metallothionein gene expression

Control of RNA polymerase I-directed transcription: recent trends

Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation

Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation

Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice

Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein

Emerging noninvasive biochemical measures: potential explanation for ethnic differences in cardiovascular risk

Induction of metallothionein by stress and its molecular mechanisms

Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid

Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals

Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

Purification and characterization of a rat liver protein that recognizes CCAAT-homologous sequences of the metallothionein promoter and trans-activates this promoter

Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells

The dual role of helix-loop–helix-zipper protein USF in ribosomal RNA gene transcription in vivo

Activation of the metallothionein-I gene promoter in response to cadmium and USF in vitro

Heat shock inhibits pre-rRNA processing at the primary site in vitro and alters the activity of some rRNA binding proteins

Rat ribosomal RNA gene can utilize primate RNA polymerase I transcription machinery: lack of absolute species specificity in rDNA transcription

Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells

The RNA polymerase I promoter-activating factor CPBF is functionally and immunologically related to the basic helix-loop-helix-zipper DNA-binding protein USF

Regulation of ribosomal gene transcription

E1BF/Ku interacts physically and functionally with the core promoter binding factor CPBF and promotes the basal transcription of rat and human ribosomal RNA genes

Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells

Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription

Effects of repetitive and non-repetitive rat rDNA enhancer elements on in vivo transcription by RNA polymerases I and II

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation

Characterization of the 130-bp repeat enhancer element of the rat ribosomal gene: functional interaction with transcription factor E1BF

Control of gene expression by lipophilic hormones

Characterization of the factor E1BF from a rat hepatoma that modulates ribosomal RNA gene transcription and its relationship to the human Ku autoantigen

Identification of a sequence within the mouse metallothionein-I gene promoter mediating its basal transcription and of a protein interacting with this element

Ara-ATP impairs 3′-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation

E1BF is an essential RNA polymerase I transcription factor with an intrinsic protein kinase activity that can modulate rRNA gene transcription

Multiple functional enhancer motifs of rat ribosomal gene

Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions

Potential role of poly(A) polymerase in the assembly of polyadenylation-specific RNP complexes

Polyadenylation of SV40 late pre-mRNA is dependent on phosphorylation of an essential component associated with the 3′ end processing machinery

Purification and characterization of a novel factor which stimulates rat ribosomal gene transcription in vitro by interacting with enhancer and core promoter elements

Tissue and species distribution of liver type and tumor type nuclear poly(A) polymerases

Polyadenylation of mRNA and its control

Glucocorticoid-induced stimulation of ribosomal gene transcription in rat hepatoma cells is mediated by modification of RNA polymerase I or an associated factor

A cis-acting sequence within the rat ribosomal DNA enhancer region can modulate RNA polymerase II-directed transcription of the metallothionein I gene in vitro

Polyadenylate polymerases from normal and cancer cells and their potential role in messenger RNA processing: a review

Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor

A 37-base pair element in the far upstream spacer region can enhance transcription of rat rDNA in vitro and can bind to the core promoter-binding factor(s)

Association of newly synthesized poly(A) polymerase with four distinct polypeptides

Association of poly(A) polymerase with U1 RNA

Inhibition of RNA polymerase I-directed transcription by novobiocin. Potential use of novobiocin as a general inhibitor of eukaryotic transcription initiation

Novobiocin inhibits initiation of RNA polymerase II-directed transcription of the mouse metallothionein-I gene independent of its effect on DNA topoisomerase II

Production of monoclonal antibodies against RNA polymerase I from nonimmunized autoimmune MRL/lpr mice and their use in rDNA transcription analysis

An enhancer element in the far upstream spacer region of rat ribosomal RNA gene

Autoantibodies against RNA polymerase I in scleroderma and Sjögren’s syndrome sera

Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene

Accurate transcription of mouse metallothionein-I gene in a fractionated nuclear extract from a rat hepatoma

Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice

Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus

Comparison of cytosolic and nuclear poly(A) polymerases from rat liver and a hepatoma: structural and immunological properties and response to NI-type protein kinases

Accurate initiation of rat ribosomal RNA gene transcription using a fractionated nuclear extract from normal liver and a hepatoma

Structural and immunological identity of rat hepatoma and fetal liver nuclear poly(A) polymerase

Characterization of a factor that can prevent random transcription of cloned rDNA and its probable relationship to poly(ADP-ribose) polymerase

Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase

Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients

A purified fraction containing RNA polymerase I that can accurately transcribe rat ribosomal RNA gene

Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis

Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver

Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase

Phosphorylation of purified glucocorticoid receptor from rat liver by an endogenous protein kinase

Anti-protein kinase NII antibodies in rheumatic autoimmune diseases

Cellular DNA replication is independent of the synthesis or accumulation of ribosomal RNA

Phosphorylation and immunology of poly(A) polymerase

Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I

Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases

RNA polymerase I in hepatoma 3924A: mechanism of enhanced activity relative to liver

Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease

Spermine-mediated phosphorylation of RNA polymerase I and its effect on transcription

Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients

Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients

Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII

A heparin-sensitive nuclear protein kinase. Purification, properties, and increased activity in rat hepatoma relative to liver

Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides

RNA polymerases in neoplasia

Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I

Turnover of the poly(A) moiety of mRNA in wheat-germ extract

Phosphorylation of nuclear poly(adenylic acid) polymerase by protein kinase: mechanism of enhanced poly(adenylic acid) synthesis

Phosphorylation of nuclear poly(A) polymerase. Comparison of liver and hepatoma enzymes

Differential effects of cordycepin triphosphate and 9 beta-D-arabinofuranosyladenine triphosphate on tRNA and 5 S RNA synthesis in isolated nuclei

Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

Effect of medroxyprogesterone acetate and testosterone on solubilized RNA polymerases and chromatin template activity in kidney from normal and androgen-insensitive (Tfm/Y) mice

Functional role of zinc in poly(A) synthesis catalyzed by nuclear poly(A) polymerase

Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase

Selective inhibition of RNA polyadenylation by Ara-ATP in vitro: a possible mechanism for antiviral action of Ara-A

Alterations in DNA-dependent RNA polymerase I and II from rat liver by thioacetamide: preferential increase in the level of chromatin-associated nucleolar RNA polymerase IB

Two functional states of poly(adenylic acid) polymerase in isolated nuclei

DNA-dependent RNA polymerases from Morris hepatomas 3924A and 7800 and from liver treated with thioacetamide

Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5′-triphosphate

Selective inhibition of initial polyadenylation in isolated nuclei by low levels of cordycepin 5″-triphosphate

Three distinct forms of DNA-dependent RNA polymerase III from kidney

Poly(adenylic acid) synthesis in isolated rat liver mitochondria

Evidence for the nuclear origin of RNA polymerases identified in the cytosol: release of enzymes from the nuclei isolated in isotonic sucrose

Response of poly(adenylic acid) polymerase in rat liver nuclei and mitochondria to stravation and re-feeding with amino acids

Poly(adenylic acid) polymerase: loss of enzyme from rat liver nuclei isolated under isotonic conditions

Inhibition of the polyadenylation reaction in vitro by polyamines

Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions

RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes

Chromatin-bound and free forms of poly(adenylic acid) polymerase in rat hepatic nuclei

Stimulation of RNA polymerases I, II and III from rat liver by spermine, and specific inhibition of RNA polymerase I by higher spermine concentrations

Early androgen action in kidney of normal and androgen-insensitive (tfm/y) mice. Changes in RNA polymerase and chromatin template activities

Mechanism of inhibition of RNA polymerase II and poly(adenylic acid) polymerase by the O-n-octyloxime of 3-formylrifamycin SV

DNA-dependent RNA polymerases I and II from kidney. Effect of polyamines on the in vitro transcription of DNA and chromatin

Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics

Genetic regulation of the androgen receptor–a study of testicular feminization in the mouse

Physicochemical and biological properties of androgen receptors

Inhibition of poly(A) polymerase by rifamycin derivatives

Specific inhibition of a primer-dependent nucleotide chain elongation reaction by the rifamycin derivative AF/013

Expression of purified mitochondrial poly(A)polymerase of hepatomas by an endogenous primer from liver

Poly(A) synthesis by RNA polymerase II from rat liver

Further studies on post-transcriptional stabilization of ribosomal precursor ribonucleic acid by phenobarbital

Role of RNA in induction of hepatic microsomal mixed function oxidases

Mammalian RNA polymerases

Mitochondrial polyriboadenylate polymerase: relative lack of activity in hepatomas

Polyriboadenylate polymerase solubilized from rat liver mitochondria

Mechanism of early effect of hydrocortisone on the transcriptional process: stimulation of the activities of purified rat liver nucleolar RNA polymerases

Evidence for extranucleolar control of RNA synthesis in the nucleolus

Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by alpha-amanitin

Specific action of alpha-amanitin on mammalian RNA polymerase protein

Mammalian RNA polymerases and their selective inhibition by amanitin

Regulation of nucleolar RNA metabolism by hydrocortisone

Altered characteristics of mammalian RNA polymerase following solubilization from nuclei

Presence of two RNA polymerase activities in liver nucleoli

Template activity of nuclear RNA fractions of the Walker tumor

Turnover of 45 S RNA of regenerating liver and Walker tumor

Composition of nucleoli isolated from mammalian cells

Effect of chloramphenicol on ribonucleic acid synthesis in liver cells in suspension

METABOLISM OF TISSUE CELLS IN SUSPENSION. SYNTHESIS OF RIBONUCLEIC ACID BY LEIVER CELLS IN SUSPENSION